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Currently, there is no clinical data showing a direct comparison between these two drugs. Use with caution in patients with history of urinary retention, angle-closure glaucoma, or increased intraocular pressure or in patients receiving anticholinergic drugs. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 28 Aug 2023), ASHP (updated 10 Aug 2023) and others.

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Other nervous system depressants, like alcohol, should also be avoided. The extended-release formulation should be administered at the same time each day. The capsule may be swallowed whole, but its contents also may be sprinkled onto a tablespoon of applesauce for immediate consumption why was flexeril discontinued without chewing the granules. The patient should rinse their mouth to ensure that they have swallowed all the contents. Muscle relaxants are sometimes abused and can cause physical dependence. Abrupt discontinuation of these drugs after long-term use can cause withdrawal symptoms.

In fact, approximately 11.5 million Americans reported abusing prescription pain relievers at least once in a 12-month period. Increased frequency and severity of adverse effects (with or without concomitant drug therapy). Cyclobenzaprine is structurally and pharmacologically related to tricyclic antidepressants. Among the most dreaded toxicities linked with cyclical antidepressants, overdoses affect fast-acting sodium channels in the cardiac conduction system. Cyclical antidepressants block the cardiac sodium channel and cause prolongation of cardiac depolarization, which manifests as QRS widening on electrocardiograms. There is also evidence that cyclical antidepressants may decrease the seizure threshold by interfering with chloride conductance on the GABA receptor.

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Robaxin (methocarbamol) and Flexeril (cyclobenzaprine) are examples of skeletal muscle relaxants (SMRs) that your healthcare provider may prescribe if you experience muscle pain. Skeletal muscle relaxants are prescription medications commonly used to treat muscle pain and muscle spasms. Cyclobenzaprine is an oral prescription drug that’s intended for short-term use.

Consult a healthcare provider to determine the best treatment option for you. Flexeril (What is Flexeril?) is a brand-name drug originally FDA-approved in 1977. The generic version of Flexeril, cyclobenzaprine, is widely available. Flexeril is structurally similar to tricyclic antidepressants and primarily works in the central nervous system (CNS). It helps reduce muscle hyperactivity through actions on the gamma- and alpha-motor systems.

It’s critical that patients follow the dosage prescribed by their physician because there’s a risk of overdose if cyclobenzaprine is taken in excess. The drug resulted in four deaths in the United States in 2016, according to the American Association of Poison Control Centers. Skeletal muscle relaxants like cyclobenzaprine and methocarbamol can cause dizziness and drowsiness. Therefore, you should wait and see how these medications affect you before driving a motor vehicle or operating machinery. Some people prefer Fexmid and Amrix over Robaxin because it is dosed once a day rather than 3 to 4 times a day. On the other hand, they can cause more adverse effects such as dry mouth and drowsiness.

Interactions

Further classified as antispasmodic agents, Robaxin and Flexeril are effective for treating acute, painful musculoskeletal conditions that cause discomfort and muscle spasms. They also have similar side effects such as drowsiness and dizziness. Taking muscle relaxants with these drugs can cause increased side effects like drowsiness and dizziness. Tizanidine may be preferred for muscle spasms caused by multiple sclerosis, cerebral palsy, and spinal cord injury. Cyclobenzaprine is used along with physical therapy and rest to relieve pain and muscle spasms. It is a muscle relaxant indicated for acute, painful musculoskeletal conditions such as neck or back pain.

• Zanaflex may be harmful to the unborn baby according to animal studies.
• If you experience neck or back strains, you may be recommended a muscle relaxant like Zanaflex or Flexeril.
• With a Zanaflex discount coupon, the retail cost can be less than $10 for 30, 4 mg tablets.

Robaxin and Flexeril are effective treatments for treating musculoskeletal pain and muscle spasms. The more effective drug is the one that works best for your specific case. It comes as an injection as well as a 500 mg or 750 mg oral tablet. Those who are prescribed Robaxin tablets need to take two or three tablets four times per day, initially. Then, one or two tablets three to four times per day or more is recommended. Flexeril can interact with serotonergic drugs like antidepressants and MAO inhibitors.

In fact, Flexeril is detectable in a urine sample for several days after consumption. Following administration of a single 15- or 30-mg dose (as extended-release capsules), peak plasma concentrations achieved in 7–8 hours. Following multiple-dose administration (30 mg once daily for 7 days as extended-release capsules), 2-5-fold accumulation in steady-state plasma concentrations observed. Insufficient evidence to indicate whether cyclobenzaprine enhances the effects of aspirin or other analgesics, or vice versa, in the management of painful musculoskeletal conditions. When butalbital is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain.

The other dosage form of this medicine is an injection solution into a muscle or into a vein. Robaxin needs to be taken three to four times a day to provide relief from muscle pain and muscle spasms. Flexeril is also covered by most Medicare and insurance plans when it’s prescribed as a generic. Immediate-release tablets are commonly prescribed to be taken multiple times per day.